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To treat thrush, after each feeding, (or every 3 hours) apply antifungal (Nystatin) solution to the mouth, gently rubbing it around to cheeks and gums with a finger. The bottle instructions recommend applying every 6 hours, but since yeast grows back in 1 1/2 hours, it will be more effective if you give half the dosage every 3 hours. Don't skip medication at nighttime. Infant Diflucan is very effective in treating yeast overgrowth (thrush). If using infant Diflucan, use as directed.This healthful bacteria will help re-balancing your baby's GI tract.